Semaglutide Treatment for Patients With Overweight or Obesity in Los Angeles

Obesity is associated with changes in the quantity, distribution, and function of fatty tissue in the body. It’s mostly a result of the interactions between genetic, metabolic, neuroendocrine, behavioral, and environmental factors involved in the regulation of energy balance and fat storage. Semaglutide has been demonstrated to reduce energy intake, reduce hunger, and increase feelings of satiety and fullness.

Lifestyle modifications such as exercise and dieting are mostly used as the first approach to overnight obesity. In cases where lifestyle modifications aren’t enough to achieve the kind of weight loss outcomes, pharmacological options are available.

The older pharmacological options for chronic weight management, including orlistat, phentermine-topiramate, and naltrexone-bupropion, typically show moderate efficacy.

The relatively new ones are the GLP-1 receptor agonists (GLP-1RA), such as Semaglutide and liraglutide. The GLP-1 receptor agonist (GLP-1RA), Semaglutide, is approved for weight management after demonstrating weight losses of about 6% over those achieved with lifestyle intervention alone in clinical trials.

Ozempic Helps Weight Loss By Making You Feel Full

Ozempic Helps Weight Loss By Making You Feel Full

Ozempic Helps Weight Loss By Making You Feel Full

The active ingredient in Ozempic is semaglutide. It works for weight loss through the activation of GLP-1 receptors in the central nervous system and modulation of neuronal activity involved in appetite regulation, food intake, and preference.

Ozempic is not approved for weight loss, but semaglutide is approved for weight loss under the name Wegovy.

Ozempic works by imitating the naturally occurring hormone, and as the hormone levels increase, the molecules send signals to your brain, telling it you’re full. It also delays digestion by increasing the time it takes for food to leave the body. It’s important to know that even with weight loss medications, lifestyle changes are still necessary for effective weight loss results. Ozempic is approved by the FDA for the treatment of diabetes.

Weight loss is a common side effect that overweight people with diabetes using Ozempic take advantage of. A study has also shown that taking these drugs for weight loss causes the body to get used to it in the long run and this can cause your weight to plateau over time.

How to use Semaglutide (Weight Loss) 2.4 Mg/0.75 Ml Subcutaneous Pen Injector

Semaglutide (Wegovy) is the first and only prescription weight-management medicine taken once weekly. It’s to be administered on the same day each week, any time of day, with or without food. It’s available in 5 different dose strengths, ranging from 0.25 mg to 2.4 mg.

Semaglutide dose must be started from a low dose and increased gradually to 2.4 mg once weekly to reduce its associated gastrointestinal side effects. Semaglutide is to be injected under your skin on the same day each week.

Avoid injecting into the same area of your skin every time to minimize the risk of skin irritation, which can feel like hard lumps under your skin.

Once-Weekly Semaglutide in Adults with Overweight or Obesity

Semaglutide is a long-acting once-weekly medication for overweight or obese adults, and it has demonstrated a highly efficacious 12.4% reduction in total body weight in comparison to placebo and lifestyle modifications. Semaglutide was FDA-approved in 2021 for controlling excess weight in patients with a BMI ≥ 30 kg/m2 or ≥ 27 kg/m2 plus at least one weight-associated comorbidity.

The semaglutide 2.4 mg increase in weekly usage is enough to provide you with your ideal weight reduction results. This medication has minimized the need for surgical management of obesity and has resulted in the reduction of obesity-related comorbidities.

What should patients know about compounded semaglutide drugs?

There are a lot of licensed pharmacies across the United States that specialize in compounding. These pharmacies mix, alter, or combine FDA-approved drugs with other ingredients for people with particular needs, such as individuals who may be allergic to a certain product in the brand-name medication.

Compounded versions of a drug become legal in the United States if the drug is limited in supply and high in demand. The drug semaglutide is popularly used for weight loss, along with diet and exercise, when in type 2 Diabetes patients. Its use has increased since the Food and Drug Administration (FDA) first approved it in 2021 which has resulted in the drug shortage and increased cost.

In May 2023, the FDA included both Ozempic and Wegovy and legalized the compounded versions of the drugs.

While this is to increase the availability of Semaglutide for those who need it, the major concern about compounded drugs, including Semaglutide, is that they are not regulated by the FDA.

This means that there is no assurance that medications purchased from compounding pharmacies or legitimate pharmacies are exactly what they claim to be. No generic form of semaglutide exists, though compounded drugs are often marketed as such, and most compounded versions of the drug are not considered safe or effective.

FDA Approves New Drug Treatment for Chronic Weight Management

The FDA approved injection for chronic weight management in adults with obesity or with overweight and at least one weight-related condition. The semaglutide 2.4 mg (Wegovy), a GLP-1 receptor agonist, is the first approved drug for chronic weight management in adults with general obesity or overweight.

The medication is indicated for chronic weight management in adults with a BMI of 27 kg/m² or greater who have at least one weight-related comorbidity, such as type 2 diabetes or hypertension.

1 mg injection was initially approved in Ozempic form for the treatment of type 2 diabetes in 2017. Semaglutide should not be used in combination with other semaglutide-containing products, other GLP-1 receptor agonists, or other medications intended for weight loss.

Has the FDA found counterfeit Ozempic in the U.S.?

FDA found a counterfeit Ozempic (semaglutide) injection of 1 milligram (mg) in the legitimate U.S. drug supply chain and seized the product. The agency recommends wholesalers, retail pharmacies, health care practitioners, and patients check the products they have received properly to distribute, use, or sell counterfeit products because some products may still be available for purchase.

The agency has analyzed the seized counterfeit products and is yet to confirm the sterility of the needles found in these products. FDA advises retail pharmacies only to purchase authentic Ozempic through authorized distributors and patients to obtain Ozempic with a valid prescription through state-licensed pharmacies.

Medications Containing Semaglutide for Type 2 Diabetes or Weight Loss

Medications Containing Semaglutide for Type 2 Diabetes or Weight Loss

Medications Containing Semaglutide for Type 2 Diabetes or Weight Loss

Medications containing Semaglutide for type 2 diabetes and weight loss include Wegovy, Ozempic, and Rybelsus. These medications work to improve satiety, reduce appetite and promote weight loss.

Oral Semaglutide Led to Similar Weight Loss as Injection

The amount of weight loss with oral semaglutide is similar to that of the weight loss with injection. There’s limited research to accurately compare the oral versus injectable semaglutide. However, you should note that all FDA-cleared for weight loss offers effective results.

How Fast Does Semaglutide Work for Weight Loss?

When taking semaglutide for weight loss, it takes about three weeks or more to see results. Sustained use of Semaglutide helps facilitate healthy weight loss that ranges from 0.5 to 2 pounds per week or more, depending on lifestyle modifications.

The Pros and Cons of Semaglutide for Weight Loss

Semaglutide’s major advantage is that it helps to lose weight and reduces the risk of complications associated with being overweight or obese. It eliminated the need for bariatric surgery if combined appropriately with diet and exercise. It works to reduce appetite significantly and minimize unhealthy cravings.

The downside of Semaglutide for weight loss is that it’s quite expensive, depending on your insurance coverage. It’s also delivered via injection most times and might not be suitable for people with a phobia of needles/ injections. It’s also associated with unpleasant side effects, and you can gain weight back if you stop using it.

Semaglutide Effects on Cardiovascular Outcomes in People With Overweight or Obesity

A few studies have shown that Semaglutide has positive cardiovascular outcomes in obese or overweight patients. Patients with overweight or obesity and diagnosed cardiovascular disorders can use Semaglutide once weekly consistently for a 20% reduction in major adverse cardiac events.

Results from a trial conducted by a Cleveland Clinic physician also show that semaglutide reduced cardiovascular events by 20% in adults who are overweight or obese.

The #1 Semaglutide Therapy Clinic Los Angeles- Renewme Medspa

The #1 Semaglutide Therapy Clinic Los Angeles- Renewme Medspa

The #1 Semaglutide Therapy Clinic Los Angeles- Renewme Medspa

RenewMe MedSpa is a reputable Semaglutide therapy clinic located in the heart of Los Angeles.  RenewMe leverages professional expertise and authentic Semaglutide formulations to help clients have an individualized experience to kick-start their transformative journey.

The Semaglutide Therapy Clinic is for obese or overweight individuals who want to take a proactive approach to losing weight and improving their health status. RenewmeMedspa offers many cutting-edge Medspa services to cater to the needs of individuals looking to achieve and maintain a healthy weight.

Schedule an appointment with RenewmeMedspa specialists to learn more about Semaglutide therapy for weight loss.

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